There is only one being who can satisfy the last aching abyss of the human heart, and that is the Lord Jesus Christ. Why our Lord is apparently so severe regarding every human relationship is because He knows that every relationship not based on loyalty to Himself will end in disaster. Our Lord trusted no man, yet He was never suspicious, never bitter. Our Lord's confidence in God and in what His grace could do for any man, was so perfect that He despaired of no one. If our trust is placed in human beings, we shall end in despairing of everyone.
But we had the sentence of death in ourselves, that we should not trust in ourselves, but in God which raiseth the dead: Who delivered us from so great a death, and doth deliver: in whom we trust that He will yet deliver us.